Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor α (ERα) re-expression

@article{Zhang2012InvestigationOE,
  title={Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor α (ERα) re-expression},
  author={Bin Zhang and Xia Zhang and Bo Tang and Peishi Zheng and Yang Zhang},
  journal={Breast Cancer Research and Treatment},
  year={2012},
  volume={136},
  pages={399-406}
}
Endocrine therapy is an important therapeutic approach for the treatment of oestrogen receptor (ER)-positive breast cancer. However, a number of these endocrine therapies can fail when the tumour loses its ER expression during treatment. To date, few studies have explored the potential clinical significance of traditional Chinese medicine in inducing the reversal of resistance to endocrine therapy in breast cancers. We used the ERα-negative MCF7 breast cancer cell line to create a tamoxifen… CONTINUE READING
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