Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.

@article{Godbillon1985InvestigationOD,
  title={Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.},
  author={Jacques A. Godbillon and D Evard and Nicole Vidon and M. N. Duval and Jean P. Schoeller and Jean Jacques Bernier and J L Hirtz},
  journal={British journal of clinical pharmacology},
  year={1985},
  volume={19 Suppl 2},
  pages={113S-118S}
}
The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma concentrations of alpha-hydroxymetoprolol and urinary excretion of the main metabolites were also measured. Plasma profiles of metoprolol after colonic and jejunal perfusion were similar, and the relative bioavailabilities of the drug from these two regions of the gut were not significantly different. The… CONTINUE READING

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