Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig.

@article{Kingsbury1999InvestigationOD,
  title={Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig.},
  author={M. Kingsbury and W. Huang and S. Giuliatti and M. Turner and Rodney J. Hunter and K. Parker and D. Sheridan},
  journal={Clinical science},
  year={1999},
  volume={96 3},
  pages={
          241-51
        }
}
Hypotension and syncope are recognized features of chronic aortic stenosis. This study examined vasomotor responses and dynamic compliance in isolated abdominal aortae after chronic constriction of the ascending aorta. Guinea pigs underwent constriction of the ascending aorta or sham operation. Sections of descending aorta were removed for studies of contractile performance and compliance. Dynamic compliance was measured using a feedback-controlled pulsatile pressure system at frequencies of 0… Expand
Restitution slope is principally determined by steady-state action potential duration
TLDR
Steady-state APD is the principal determinant of the slope of the ventricular electrical restitution curve and concomitant changes in tissue refractoriness act to reduce susceptibility to sustained VF. Expand