Investigation of degradation products in a topical gel containing erythromycin and benzoyl peroxide by liquid chromatography-mass spectrometry.

@article{Haghedooren2006InvestigationOD,
  title={Investigation of degradation products in a topical gel containing erythromycin and benzoyl peroxide by liquid chromatography-mass spectrometry.},
  author={Erik Haghedooren and S KiranKumarRajuBhupathiRajuV and Pieter Dehouck and Cindy Govaerts and Ann Van Schepdael and Jos a Hoogmartens and Erwin Adams},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2006},
  volume={41 1},
  pages={165-75}
}
Benzamycin, combining benzoyl peroxide and erythromycin, is a topical gel used in the treatment of acne vulgaris. Because of the reactivity of benzoyl peroxide, preparations containing both erythromycin and benzoyl peroxide might be unstable and degradation products could be formed. To investigate and identify these latter products, a gradient-based liquid… CONTINUE READING