Investigation of clinical pharmacokinetic variability of an opioid antagonist through physiologically based absorption modeling.

Abstract

Identifying the source of inter- and/or intrasubject variability in pharmacokinetics (PK) provides fundamental information in understanding the pharmacokinetics-pharmacodynamics relationship of a drug and project its efficacy and safety in clinical populations. This identification process can be challenging given that a large number of potential causes… (More)
DOI: 10.1002/jps.23629

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