Investigation of cellular and humoral immune responses to whole cell and acellular pertussis vaccines.

@article{Canthaboo2000InvestigationOC,
  title={Investigation of cellular and humoral immune responses to whole cell and acellular pertussis vaccines.},
  author={Catpagavalli Canthaboo and Livy H. Williams and Dorothy K-L Xing and Michael J. Corbel},
  journal={Vaccine},
  year={2000},
  volume={19 6},
  pages={637-43}
}
New generation acellular pertussis vaccines were compared with the established whole cell pertussis vaccine for the induction of humoral and cellular immune-responses in mice. At the same time, the in vivo protective effect of these two types of vaccine was also compared in both intracerebral (ic) and aerosol challenge models. In general, whole cell vaccine induced lower antibody titres to pertussis toxin, filamentous haemagglutinin and pertactin than the acellular vaccine. Nitric oxide… CONTINUE READING
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