Investigation of c-myc and p53 Gene Alterations in the Tumor and Surgical Borderline Tissues of NSCLC and Effects on Clinicopathologic Behavior: By the FISH Technique

@article{Yakut2003InvestigationOC,
  title={Investigation of c-myc and p53 Gene Alterations in the Tumor and Surgical Borderline Tissues of NSCLC and Effects on Clinicopathologic Behavior: By the FISH Technique},
  author={Tahsin Yakut and Unal Egeli and Cengiz Gebitekin},
  journal={Lung},
  year={2003},
  volume={181},
  pages={245-258}
}
Genetic alterations on the primary tumoral tissues and surgical borderline tissues of 51 patients with NSCLC on which radiotherapy and chemotherapy had not been performed were analyzed by using the FISH method with locus-specific probes for p53 tumor suppressor gene and c-myc oncogene and centromere-specific probes for chromosome 17 and chromosome 8 on which these genes are located. P53 deletions were detected in 7 patients (13.7%), c-myc amplification in 4 patients (7.8%), monosomy 17 in 2… CONTINUE READING

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