Investigation of bn-44 peptide fragments using high resolution mass spectrometry and isotope labeling.

@article{Wang2014InvestigationOB,
  title={Investigation of bn-44 peptide fragments using high resolution mass spectrometry and isotope labeling.},
  author={Bing Wang and Jiayi Joey Yu and Huixin Wang and Zhonglin Wei and Xinhua Guo and Zhaohui Xiao and Zhoufang Zeng and Wei Bo Kong},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2014},
  volume={25 12},
  pages={
          2116-24
        }
}
An N-terminal deuterohemin-containing hexapeptide (DhHP-6) was designed as a short peptide cytochrome c (Cyt c) mimetic to study the effect of N-terminal charge on peptide fragmentation pathways. This peptide gave different dissociation patterns than normal tryptic peptides. Upon collision-induced dissociation (CID) with an ion trap mass spectrometer, the singly charged peptide ion containing no added proton generated abundant and characteristic bn-44 ions instead of bn-28 (an) ions. Studies by… CONTINUE READING
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