Investigation of bacterial growth on mixed substrates: experimental evaluation of cybernetic models.

  title={Investigation of bacterial growth on mixed substrates: experimental evaluation of cybernetic models.},
  author={Dhinakar S Kompala and Doraiswami Ramkrishna and N B Jansen and George T. Tsao},
  journal={Biotechnology and bioengineering},
  volume={28 7},
Cybernetic models, developed earlier by the authors, have been evaluated experimentally for the growth of Klebsiella oxytoca in batch cultures using mixed substrates from glucose, xylose, arabinose, lactose, and fructose. Based entirely on information procured from batch growth on single substrates, the models accurately predict without further parameter fitting, diauxic growth on mixed substrates, automatically predicting the order in which the substrates are consumed. Even triauxic growth on… CONTINUE READING


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