Investigation of association between the TRAF family genes and RA susceptibility.

  title={Investigation of association between the TRAF family genes and RA susceptibility.},
  author={Catherine Potter and Stephen Eyre and Andrew Cope and Jane Worthington and Anne Barton},
  journal={Annals of the rheumatic diseases},
  volume={66 10},
OBJECTIVE The tumour necrosis factor (TNF) receptor-associated factor (TRAF) family is important in activating multiple inflammatory and immune related processes induced by cytokines such as TNFalpha and interleukin-1. These genes therefore represent strong candidate susceptibility factors for rheumatoid arthritis (RA). A study was undertaken to investigate the association between single nucleotide polymorphisms (SNPs) spanning six TRAF genes and RA in a British population. METHODS Twenty… CONTINUE READING


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