Investigation of age-related cognitive decline using mice as a model system: behavioral correlates.

@article{Murphy2006InvestigationOA,
  title={Investigation of age-related cognitive decline using mice as a model system: behavioral correlates.},
  author={Geoffrey G. Murphy and Nancy P. Rahnama and Alcino J. Silva},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year={2006},
  volume={14 12},
  pages={1004-11}
}
OBJECTIVE With recent advances in molecular genetics, mouse models have been generated for a number of disease states. Recently, the authors and others have begun to examine normal age-related cognitive decline using mice as a model system. In this article, and the companion article that follows, the authors present data intended to better parameterize the aging phenotype in mice and examine the possible underlying neuronal mechanisms with special emphasis on age-related changes in calcium… CONTINUE READING

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