• Corpus ID: 29975494

Investigation of acute toxicity of Malathion and Cypermethrin on Clinico-hematological parameters in female New Zealand White Rabbits (Oryctolagus cuniculus)

  title={Investigation of acute toxicity of Malathion and Cypermethrin on Clinico-hematological parameters in female New Zealand White Rabbits (Oryctolagus cuniculus)},
  author={Mussarrat Shaheen and Ali Muhammad Yousafzai},
The aim of the present study was to find the clinical and hematological alterations in female rabbits exposed orally to Malathion and Cypermethrin at a dose of 75mg/kg body weight for seven days through gavage. Animals were divided into three groups i.e. A, B and C comprised of three rabbits each. Group A was considered as control. Group B was intoxicated with Malathion while C was Cypermethrin intoxicated group. All the animals were monitored twice a day for clinical signs. Signs like grinding… 

Figures and Tables from this paper



Effect of cypermethrin on clinico-haematological parameters in rabbits.

It was concluded that CY is not safe for animals in high doses because it affected the haematological parameters in dose dependent manner and indicated that rabbits were suffering from anaemia.

Effects of six months' feeding of cypermethrin on the blood and liver of albino rats.

A cypermethrin-mixed diet was fed uninterrupted to male albino rats for six months to evaluate toxicity in nontarget organisms, suggesting liver and possibly pancreas malfunction.

Cypermethrin induced anaemia in male rabbits.

It was concluded that macrocytic hypochromic anaemia was induced in the male rabbits due to CY treatment, but not in the females at the dose levels administered during the study.

Plasma and RBCs antioxidant status in occupational male pesticide sprayers.

Pyrethroid insecticide-induced alterations in mammalian synaptic membrane potential.

Data indicate that type I and type II phenoxybenzyl pyrethroids act potently and stereoselectively on the voltage-sensitive sodium channel to increase sodium influx into synaptic terminals producing membrane depolarization and neurotransmitter release and show that pyrethroid-induced alterations in synaptosomal membrane potential is a sensitive measure ofpyrethroid action on the sodium channel and of pyrethoid toxicity.

Neuronal ion channels as the target sites of insecticides.

It appears that the sodium channel and the GABA system merit continuing efforts for development of newer and better insecticides.

Fate of Pesticides in the Environment and its Bioremediation

Bioremediation, as one of the most environmentally‐sound and cost‐effective methods for the decontamination and detoxification of a pesticide‐contaminated environment is discussed especially considering the factors affecting the biodegradability of pesticides such as biological factors and the characteristics of the chemical compounds.