Investigation of a thiazolidinone derivative as an allosteric modulator of follicle stimulating hormone receptor: evidence for its ability to support follicular development and ovulation.

@article{Sriraman2014InvestigationOA,
  title={Investigation of a thiazolidinone derivative as an allosteric modulator of follicle stimulating hormone receptor: evidence for its ability to support follicular development and ovulation.},
  author={Venkataraman Sriraman and Deborah Denis and Daniel G de Matos and Henry Yu and Stephen L. Palmer and Selva G Nataraja},
  journal={Biochemical pharmacology},
  year={2014},
  volume={89 2},
  pages={
          266-75
        }
}
FSH signalling through its cognate receptor is critical for follicular development and ovulation. An earlier study had documented thiazolidinone derivatives to activate FSH receptor expressed in CHO cells and rat granulosa cells; however development of this compound for clinical use was halted for unobvious reasons. The objective of the current study is to extend the previous investigations in detail on the ability of thiazolidinone derivative (henceforth referred to as Compound 5) to activate… CONTINUE READING
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