Investigation of a primary requirement of organ preservation solutions: supplemental buffering agents improve hepatic energy production during cold storage.

@article{Churchill1998InvestigationOA,
  title={Investigation of a primary requirement of organ preservation solutions: supplemental buffering agents improve hepatic energy production during cold storage.},
  author={Thomas A. Churchill and Norman Mark Kneteman},
  journal={Transplantation},
  year={1998},
  volume={65 4},
  pages={551-9}
}
BACKGROUND This study was designed to investigate the effects of a modified University of Wisconsin (UW) solution supplemented with one of four buffering agents (histidine, bicine [N,N-bis(2-hydroxyethyl)glycine], tricine [N-tris(hydroxymethyl)methylglycine], and Tris) on liver metabolism during cold ischemic storage. METHODS Rat livers were flushed and… CONTINUE READING