Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition.

@article{Caroli2012InvestigationOA,
  title={Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition.},
  author={Antonia Caroli and Silvia Simeoni and Rosalba Lepore and Anna Tramontano and Allegra Via},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={417 1},
  pages={576-81}
}
Schistosoma mansoni and Plasmodium falciparum are pathogen parasites that spend part of their lives in the blood stream of the human host and are therefore heavily exposed to fluxes of toxic reactive oxygen species (ROS). SmTGR, an essential enzyme of the S. mansoni ROS detoxification machinery, is known to be inhibited by Auranofin although the inhibition mechanism has not been completely clarified. Auranofin also kills P. falciparum, even if its molecular targets are unknown. Here, we used… CONTINUE READING