Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei


There is an urgent need for new drugs for the treatment of tropical parasitic diseases such as human African trypanosomiasis, which is caused by Trypanosoma brucei. The enzyme trypanothione reductase (TryR) is a potential drug target within these organisms. Herein we report the screening of a 62,000 compound library against T. brucei TryR. Further work was… (More)
DOI: 10.1002/cmdc.200900262


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