Investigation of Solid-State Reactions Using Variable Temperature X-Ray Powder Diffractrometry. I. Aspartame Hemihydrate

@article{Rastogi2004InvestigationOS,
  title={Investigation of Solid-State Reactions Using Variable Temperature X-Ray Powder Diffractrometry. I. Aspartame Hemihydrate},
  author={S. Rastogi and M. Zakrzewski and R. Suryanarayanan},
  journal={Pharmaceutical Research},
  year={2004},
  volume={18},
  pages={267-273}
}
AbstractPurpose. The object of this study was to demonstrate the applicability of variable temperature X-ray powder diffractometry (XRD) to investigate solid-state reactions using aspartame as a model compound. Methods. Aspartame exists as a hemihydrate (ASH) under ambient conditions and converts to aspartame anhydrate (ASA) at ∼130°C. ASA on further heating to ∼180°C undergoes decomposition (intramolecular cyclization) to form a diketopiperazine derivative (DKP). The dehydration as well as the… Expand
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