Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat.


BACKGROUND Timolol is clinically administered topically (ocular) to reduce intraocular pressure and treat open-angle glaucoma. Ocular administration of timolol in low doses (0.5% w/v in the form of eye drops) has led to challenges for in vivo metabolite identification. An understanding of drug metabolism in the eye is important for clinical ocular… (More)
DOI: 10.2174/1872312811666170911122919