Investigation of MDMA-related agents in rats trained to discriminate MDMA from saline.

@article{Glennon1992InvestigationOM,
  title={Investigation of MDMA-related agents in rats trained to discriminate MDMA from saline.},
  author={Richard A Glennon and R A Higgs},
  journal={Pharmacology, biochemistry, and behavior},
  year={1992},
  volume={43 3},
  pages={759-63}
}
To determine whether metabolite-related analogs of N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) produce stimulus effects similar to those of the parent compound, and to determine the structural requirements associated with the MDMA stimulus, several MDMA analogs were examined in tests of stimulus generalization using rats trained to discriminate 1.5 mg/kg MDMA from saline. Although several of the analogs produced up to 50-60% MDMA-appropriate responding, none [with the exception… CONTINUE READING

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