Investigation of Intrinsically Disordered Proteins through Exchange with Hyperpolarized Water.

Abstract

Hyperpolarized water can selectively enhance NMR signals of rapidly exchanging protons in osteopontin (OPN), a metastasis-associated intrinsically disordered protein (IDP), at near-physiological pH and temperature. The transfer of magnetization from hyperpolarized water is limited to solvent-exposed residues and therefore selectively enhances signals in 1 H… (More)
DOI: 10.1002/anie.201608903

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Cite this paper

@article{Kurzbach2017InvestigationOI, title={Investigation of Intrinsically Disordered Proteins through Exchange with Hyperpolarized Water.}, author={Dennis Kurzbach and Estel Canet and Andrea Gabriele Flamm and Aditya Jhajharia and Emmanuelle M M Weber and Robert Konrat and Geoffrey Bodenhausen}, journal={Angewandte Chemie}, year={2017}, volume={56 1}, pages={389-392} }