Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents

@article{Wang2014InvestigationOI,
  title={Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents},
  author={J. Wang and M. Kaiser and B. Copp},
  journal={Marine Drugs},
  year={2014},
  volume={12},
  pages={3138 - 3160}
}
  • J. Wang, M. Kaiser, B. Copp
  • Published 2014
  • Biology, Medicine
  • Marine Drugs
  • Pure compound screening has previously identified the indolglyoxylamidospermidine ascidian metabolites didemnidine A and B (2 and 3) to be weak growth inhibitors of Trypanosoma brucei rhodesiense (IC50 59 and 44 μM, respectively) and Plasmodium falciparum (K1 dual drug resistant strain) (IC50 41 and 15 μM, respectively), but lacking in selectivity (L6 rat myoblast, IC50 24 μM and 25 μM, respectively). To expand the structure–activity relationship of this compound class towards both parasites… CONTINUE READING
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