Investigation of Human Albumin-Induced Circular Dichroism in Dansylglycine

  title={Investigation of Human Albumin-Induced Circular Dichroism in Dansylglycine},
  author={Fernanda S. Graciani and Valdecir Farias Ximenes},
  booktitle={PloS one},
Induced circular dichroism (ICD), or induced chirality, is a phenomenon caused by the fixation of an achiral substance inside a chiral microenvironment, such as the hydrophobic cavities in proteins. Dansylglycine belongs to a class of dansylated amino acids, which are largely used as fluorescent probes for the characterization of the binding sites in albumin. Here, we investigated the ICD in dansylglycine provoked by its binding to human serum albumin (HSA). We found that the complexation of… CONTINUE READING
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