Investigation of Elimination Rate, Persistent Subpopulation Removal, and Relapse Rates of Mycobacterium tuberculosis by Using Combinations of First-Line Drugs in a Modified Cornell Mouse Model

@inproceedings{Hu2016InvestigationOE,
  title={Investigation of Elimination Rate, Persistent Subpopulation Removal, and Relapse Rates of Mycobacterium tuberculosis by Using Combinations of First-Line Drugs in a Modified Cornell Mouse Model},
  author={Yanmin Hu and Henry E Pertinez and F{\'a}tima Ortega-Muro and Laura Alameda-Martin and Yingjun Liu and Alessandro Schipani and Geraint Davies and Anthony R. M. Coates},
  booktitle={Antimicrobial agents and chemotherapy},
  year={2016}
}
Currently, the most effective tuberculosis control method involves case finding and 6 months of chemotherapy. There is a need to improve our understanding about drug interactions, combination activities, and the ability to remove persistent bacteria using the current regimens, particularly in relation to relapse. We aimed to investigate the therapeutic effects of three main components, rifampin (RMP), isoniazid (INH), and pyrazinamide (PZA), in current drug regimens using a modified version of… CONTINUE READING