Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound.


We evaluated antitrichomonal effects of δ opioid receptor (DOR) agonists and antagonists. Although all the agonists were inactive, the DOR antagonists BNTX (2a) and its derivatives 2b-d showed antitrichomonal activity with MIC of 20-40 μM. In addition, the development of a more effective synthetic method for the BNTX derivatives was achieved by using the… (More)
DOI: 10.1016/j.bmcl.2015.06.002


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