Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: association with higher body mass index.

@article{Monteleone2008InvestigationO3,
  title={Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: association with higher body mass index.},
  author={Palmiero Monteleone and Alfonso Tortorella and Ludovico Docimo and M N Maldonato and Benedetta Canestrelli and Luca De Luca and Mario Maj},
  journal={Neuroscience letters},
  year={2008},
  volume={435 1},
  pages={30-3}
}
Loss of circadian patterning of metabolism-related functions seems to play a role in the pathogenesis of obesity; therefore, it is reasonable to hypothesize that the functional 3111T/C single nucleotide polymorphism (SNP) of the (Circadian locomotor output cycles kaput) CLOCK gene may have a part in the genetic susceptibility to obesity. The aim of this study was to assess the frequencies of 3111T/C CLOCK gene SNP in overweight/obese subjects with or without binge eating disorder (BED) as… CONTINUE READING
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