Investigation of 3 Industry-Wide Applied Storage Conditions for Compound Libraries

  title={Investigation of 3 Industry-Wide Applied Storage Conditions for Compound Libraries},
  author={Pierre E Ilouga and Dirk Winkler and Christiane Kirchhoff and Bernd Schierholz and Julian W{\"o}lcke},
  journal={Journal of Biomolecular Screening},
  pages={21 - 32}
The appropriate storage conditions for a compound file are a crucial factor for the success of drug discovery projects. In this study, 778 highly diverse compounds dissolved in 100% DMSO were stored under 3 industry-wide accepted storage conditions, and the compound integrity was monitored for a period of 6 months. The storage conditions selected were (1) under argon at +15 °C, (2) under argon at -20 °C, and (3) under ambient atmosphere at -20 °C. Each sample was assessed every 4 weeks by… 

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