Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study.

@article{Sharp2006InvestigationIT,
  title={Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study.},
  author={Caroline J Sharp and Alison J. Reeve and Sue D Collins and Jo C Martindale and Scott G. Summerfield and Becky S Sargent and Simon T. Bate and Iain Chessell},
  journal={British journal of pharmacology},
  year={2006},
  volume={148 6},
  pages={845-52}
}
1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor CNS penetrance (blood:brain, 1:<0.05), and was therefore administered intravenously in chronic constriction injury (CCI)- and sham-operated rats to study the involvement of P2X(3) subunit-containing receptors in the periphery in neuropathic pain. A-317491 and Compound A were administered topically to the spinal cord to investigate the… CONTINUE READING

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