Corpus ID: 90162459

Investigation into the role of HER2 receptor signalling in Hypoxia-inducible Factor Regulation in breast cancer

  title={Investigation into the role of HER2 receptor signalling in Hypoxia-inducible Factor Regulation in breast cancer},
  author={E. Jarman},


HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells
It is shown that the ERα-expressing breast cancer cells MCF-7, CAMA-1, and T47D are less sensitive to antiestrogens when hypoxic, and inhibition of HIFs by FM19G11 restores antiestrogen sensitivity in resistant cells.
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
This chemical genetic analysis describes a molecular mechanism by which translation of the HIF-2a message is maintained during conditions of cellular hypoxia through inhibition of IRP-1-dependent repression.
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
PT2385 represents a novel class of therapeutics for the treatment of RCC with potent preclincal efficacy as well as improved tolerability relative to current agents that target the VEGF pathway.
ErbB family receptor inhibitors as therapeutic agents in breast cancer: Current status and future clinical perspective
The mechanism of action, preclinical and clinical trial data of the agents that are in use for targeting the EGFR/HER‐2 pathway and the current status and the future clinical trial promises of these agents have been pondered to provide better and more efficacious treatment strategies for breast cancer patients.
Passing the baton: the HIF switch.
The significance of the HIF switch and the relation between Hif-1 and HIF-2 under both physiological and pathophysiological conditions are reviewed.
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
Using chromatin immunoprecipitation linked to high throughput sequencing, HIF-binding sites across the genome are identified, indicating that these sites operate over long genomic intervals, and epigenetic regulation of chromatin may have an important role in defining the response to hypoxia.
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
An online tool to draw survival plots, which can be used to assess the relevance of the expression levels of various genes on the clinical outcome both in untreated and treated breast cancer patients, and which validated the capability of microarrays to determine estrogen receptor status in 1,231 patients.
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts*
Genome-wide chromatin immunoprecipitation using antibodies to two major HIF-α subunits, and correlated the results with genome-wide transcript profiling, demonstrated that binding to this motif was highly selective, with binding enriched at distinct regions both upstream and downstream of the transcriptional start.
HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.
It is shown that HIF-1alpha is an independent prognostic factor for distant metastasis- free survival and disease-free survival in multivariate analysis and overexpression of Hif-1 alpha or CA IX correlates with a poor prognosis in breast cancer.
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
The results indicated that HER2 can induce HIF activation via the activation of Akt suggesting that activation of Her2/Akt pathway may promote angiogenesis independent of hypoxia, which may have important implications for the oncogenic activity of HER2 and Akt.