Investigation and characterization of receptors for pituitary adenylate cyclase-activating polypeptide in human brain by radioligand binding and chemical cross-linking.

@article{Suda1991InvestigationAC,
  title={Investigation and characterization of receptors for pituitary adenylate cyclase-activating polypeptide in human brain by radioligand binding and chemical cross-linking.},
  author={Kitaru Suda and Davey M. Smith and Mohammad A. Ghatei and Jenifer K Murphy and Stephen R. Bloom},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={72 5},
  pages={
          958-64
        }
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a novel peptide of hypothalamic origin which increases adenylate cyclase activity in rat anterior pituitary cell cultures. The 38-amino acid peptide shows a close sequence homology to vasoactive intestinal peptide (VIP). Binding sites for PACAP in membranes from postmortem human brain tissue were studied using [125I]PACAP27 as the radioligand. High specific binding sites (amount of specific binding measured at 0.25 nM [125I]PACAP27… CONTINUE READING

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