Investigating the stability of the nonionic surfactants tocopheryl polyethylene glycol succinate and sucrose laurate by HPLC-MS, DAD, and CAD.

@article{Christiansen2011InvestigatingTS,
  title={Investigating the stability of the nonionic surfactants tocopheryl polyethylene glycol succinate and sucrose laurate by HPLC-MS, DAD, and CAD.},
  author={A. T. Christiansen and Thomas Backensfeld and Silke K{\"u}hn and Werner Weitschies},
  journal={Journal of pharmaceutical sciences},
  year={2011},
  volume={100 5},
  pages={1773-82}
}
High-performance liquid chromatography (HPLC) methods using a charged aerosol detector (CAD), a mass selective detector (MSD), and a diode array detector (DAD) were developed to characterize the nonionic surfactants d-α-tocopheryl polyethylene glycol (1000) succinate (TPGS) and Surfhope sugar ester D-1216 (sucrose laurate). The molecular structure and the heterogeneous composition resulting from different isomers and various lengths of polyethylene glycol (PEG) chains make it difficult to… CONTINUE READING
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