Investigating the role of shape on the biological impact of gold nanoparticles in vitro.

  title={Investigating the role of shape on the biological impact of gold nanoparticles in vitro.},
  author={Furong Tian and Martin J. D. Clift and Alan R Casey and Pablo Del Pino and Beatriz Pelaz and Jo{\~a}o Conde and Hugh J. Byrne and Barbara Rothen-Rutishauser and Giovani Estrada and Jesus Maria de la Fuente and Tobias Stoeger},
  volume={10 17},
AIM To investigate the influence of gold nanoparticle geometry on the biochemical response of Calu-3 epithelial cells. MATERIALS & METHODS Spherical, triangular and hexagonal gold nanoparticles (GNPs) were used. The GNP-cell interaction was assessed via atomic absorption spectroscopy (AAS) and transmission electron microscopy (TEM). The biochemical impact of GNPs was determined over 72 h at (0.0001-1 mg/ml). RESULTS At 1 mg/ml, hexagonal GNPs reduced Calu-3 viability below 60%, showed… CONTINUE READING
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