Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease

@article{Sassi2014InvestigatingTR,
  title={Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease},
  author={C. Sassi and R. Guerreiro and R. Gibbs and J. Ding and M. Lupton and C. Troakes and S. Al-Sarraj and Michael Niblock and Jean-Marc Gallo and J. Adnan and R. Killick and K. Brown and C. Medway and J. Lord and J. Turton and J. Br{\'a}s and K. Morgan and J. Powell and A. Singleton and J. Hardy},
  journal={Neurobiology of Aging},
  year={2014},
  volume={35},
  pages={2881.e1 - 2881.e6}
}
  • C. Sassi, R. Guerreiro, +17 authors J. Hardy
  • Published 2014
  • Medicine
  • Neurobiology of Aging
  • The overlapping clinical and neuropathologic features between late-onset apparently sporadic Alzheimer's disease (LOAD), familial Alzheimer's disease (FAD), and other neurodegenerative dementias (frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, and Creutzfeldt-Jakob disease) raise the question of whether shared genetic risk factors may explain the similar phenotype among these disparate disorders. To investigate this intriguing hypothesis, we analyzed rare… CONTINUE READING
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