Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

@article{Borbone2012InvestigatingTR,
  title={Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.},
  author={Nicola Borbone and Mariarosaria Bucci and Giorgia Oliviero and Elena Morelli and Jussara Amato and Valentina D'Atri and Stefano D'Errico and Valentina Vellecco and Giuseppe Antonio Cirino and Gennaro Piccialli and Caterina Fattorusso and Michela Varra and Luciano Mayol and Marco Persico and Maria Scuotto},
  journal={Journal of medicinal chemistry},
  year={2012},
  volume={55 23},
  pages={10716-28}
}
An acyclic pyrimidine analogue, containing a five-member cycle fused on the pyrimidine ring, was synthesized and introduced at position 7 or 12 of the 15-mer oligodeoxynucleotide GGTTGGTGTGGTTGG, known as thrombin-binding aptamer (TBA). Characterization by 1H NMR and CD spectroscopies of the resulting aptamers, TBA-T7b and TBA-T12b, showed their ability to fold into the typical antiparallel chairlike G-quadruplex structure formed by TBA. The apparent CD melting temperatures indicated that the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
8 Citations
30 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…