Investigating the role of F-actin in human immunodeficiency virus assembly by live-cell microscopy.

@article{Rahman2014InvestigatingTR,
  title={Investigating the role of F-actin in human immunodeficiency virus assembly by live-cell microscopy.},
  author={Sheikh Abdul Rahman and Peter Koch and Julian Weichsel and William J. Godinez and Ulrich S. Schwarz and Karl Rohr and Don C Lamb and Hans-Georg Kr{\"a}usslich and Barbara M{\"u}ller},
  journal={Journal of virology},
  year={2014},
  volume={88 14},
  pages={7904-14}
}
Human immunodeficiency virus type 1 (HIV-1) particles assemble at the plasma membrane, which is lined by a dense network of filamentous actin (F-actin). Large amounts of actin have been detected in HIV-1 virions, proposed to be incorporated by interactions with the nucleocapsid domain of the viral polyprotein Gag. Previous studies addressing the role of F-actin in HIV-1 particle formation using F-actin-interfering drugs did not yield consistent results. Filamentous structures pointing toward… CONTINUE READING
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