Investigating the predictability of essential genes across distantly related organisms using an integrative approach

@inproceedings{Deng2011InvestigatingTP,
  title={Investigating the predictability of essential genes across distantly related
organisms using an integrative approach},
  author={Jingyuan Deng and Lei Deng and Shengchang Su and Minlu Zhang and Xiaodong Lin and Lan Wei and Ali A. Minai and Daniel J Hassett and Long Jason Lu},
  booktitle={Nucleic acids research},
  year={2011}
}
Rapid and accurate identification of new essential genes in under-studied microorganisms will significantly improve our understanding of how a cell works and the ability to re-engineer microorganisms. However, predicting essential genes across distantly related organisms remains a challenge. Here, we present a machine learning-based integrative approach that reliably transfers essential gene annotations between distantly related bacteria. We focused on four bacterial species that have well… CONTINUE READING
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