Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia.
@article{Bae2015InvestigatingTP,
title={Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia.},
author={Joon Seol Bae and Jason-Y. Kim and Byung lae Park and Hyun Sub Cheong and Jeong-Hyun Kim and Suhg Namgoong and Ji-On Kim and Chul-Soo Park and Bong Jo Kim and Cheol-Soon Lee and Migyung Lee and Woo Hyuk Choi and T-M Shin and Jaeuk Hwang and Hyoung Doo Shin and Sung-Il Woo},
journal={Molecular medicine reports},
year={2015},
volume={11 4},
pages={
2975-80
}
}Schizophrenia is a serious mental disorder that is affected by genetic and environmental factors. As the disease has a high heritability rate, genetic studies identifying candidate genes for schizophrenia have been conducted in various populations. The gene for human Ran‑binding protein 9 (RANBP9) is a newly discovered candidate gene for schizophrenia. As RANBP9 is a small guanosine‑5'‑triphosphate‑binding protein that interacts with the disrupted in schizophrenia 1 protein, it is considered to…
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References
SHOWING 1-10 OF 30 REFERENCES
Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality
- Psychology, MedicineJournal of Human Genetics
- 2009
The results of the present study provide the evidence that in a Korean population, COMT on the 22q11 locus is likely involved in the development of schizophrenia, but not in the SPEM function abnormality.
Association of RANBP1 haplotype with smooth pursuit eye movement abnormality
- Medicine, PsychologyAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2011
The results of present study provide the evidence that RANBP1 on 22q11.21 locus might be causally related to the SPEM abnormality rather than the development of schizophrenia.
Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.
- Psychology, MedicineAmerican journal of human genetics
- 2001
The results of karyotypic, clinical, and ERP investigations of this family suggest that the recently described genes DISC1 and DISC2, which are directly disrupted by the breakpoint on chromosome 1, may have a role in the development of a disease phenotype that includes schizophrenia as well as unipolar and bipolar affective disorders.
Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia
- Psychology, MedicineMolecular Psychiatry
- 2001
A contiguous clone map of PACs and cosmids extending across at least 400 kb of the chromosome 1 translocation breakpoint region has provided the basis for examination of the genomic structure of DISC1, a candidate gene potentially involved in the aetiology of major psychiatric illness.
Screening schizophrenic patients for mutations in the amyloid precursor protein gene.
- Medicine, PsychologyPsychiatric genetics
- 1994
Recent evidence suggests that the alanine to valine mutation in codon 713 in a single case of chronic familial schizophrenia with cognitive deficits is indeed pathogenic for the clinical phenotype observed; the mechanisms involved are outlined.
Evidence for white matter abnormalities in schizophrenia
- Medicine, PsychologyCurrent opinion in psychiatry
- 2005
Advances in new imaging techniques likely account for the renewed interest in investigating white matter abnormalities in schizophrenia, with over 30 new articles published on this topic in the last 12 months compared with 11 the year before.
Distinct cerebrospinal fluid amyloid‐beta peptide signatures in cognitive decline associated with Alzheimer's disease and schizophrenia
- Biology, MedicineElectrophoresis
- 2012
The quite comparable reduction of CSF Aβ1–42 in AD and in elderly SCZ patients reflects different pathophysiological dynamics in ageing brain, and suggests a dysmetabolism of amyloid precursor protein in olderSCZ patients.
Schizophrenia: a concise overview of incidence, prevalence, and mortality.
- Medicine, PsychologyEpidemiologic reviews
- 2008
The epidemiology of schizophrenia is characterized by prominent variability and gradients that can help guide future research.
Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain
- BiologyFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2012
It is shown that RanBP9 overexpression resulted in > 2‐fold increase in Aβ40 levels as early as 4 mo of age, and increased Aβ levels were translated to increased deposition of amyloid plaques.




