Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles

@article{Husseini2002InvestigatingTM,
  title={Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles},
  author={Ghaleb A. Husseini and Christopher M Runyan and William G. Pitt},
  journal={BMC Cancer},
  year={2002},
  volume={2},
  pages={20 - 20}
}
This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and without the action of ultrasound, while drug uptake was increased with the application of ultrasound. In this study, the amount of uptake of two fluorescent probes, Lysosensor Green (a pH-sensitive probe) and Cell Tracker Orange CMTMR (a pH-independent probe), was measured in HL-60 and… CONTINUE READING

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