Investigating the linkage between disease-causing amino acid variants and their effect on protein stability and binding.

@article{Peng2016InvestigatingTL,
  title={Investigating the linkage between disease-causing amino acid variants and their effect on protein stability and binding.},
  author={Yunhui Peng and Emil Alexov},
  journal={Proteins},
  year={2016},
  volume={84 2},
  pages={232-9}
}
Single amino acid variations (SAV) occurring in human population result in natural differences between individuals or cause diseases. It is well understood that the molecular effect of SAV can be manifested as changes of the wild type characteristics of the corresponding protein, among which are the protein stability and protein interactions. Typically the effect of SAV on protein stability and interactions was assessed via the changes of the wild type folding and binding free energies. However… CONTINUE READING