Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals.

@article{Boraxbekk2015InvestigatingTI,
  title={Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals.},
  author={C. J. Boraxbekk and David J Ames and Nicole A. Kochan and Teresa Y. H. Lee and Anbupalam Thalamuthu and Wei Wen and Nicola J Armstrong and John B. J. Kwok and Peter R. Schofield and Simone Reppermund and Margaret J. Wright and Julian N. Trollor and Henry Brodaty and Perminder S. Sachdev and Karen Mather},
  journal={Neuropsychologia},
  year={2015},
  volume={78},
  pages={10-7}
}
The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data… CONTINUE READING
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