Investigating the effects of L- to D-amino acid substitution and deamidation on the activity and membrane interactions of antimicrobial peptide anoplin.

@article{Won2011InvestigatingTE,
  title={Investigating the effects of L- to D-amino acid substitution and deamidation on the activity and membrane interactions of antimicrobial peptide anoplin.},
  author={Amy Hye Won and Mourin Khan and Sorin Gustin and Akuvi Akpawu and Deeptee Seebun and Tyler J. Avis and Bonnie Leung and Adam P Hitchcock and Anatoli Ianoul},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1808 6},
  pages={1592-600}
}
Isolated from the venom sac of solitary spider wasp, Anoplius samariensis, anoplin is the smallest linear α-helical antimicrobial peptide found naturally with broad spectrum activity against both Gram-positive and Gram-negative bacteria, and little hemolytic activity toward human erythrocytes. Deamidation was found to decrease the peptide's antibacterial… CONTINUE READING