Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease

@article{Wiltshire2008InvestigatingTA,
  title={Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease},
  author={Steven Wiltshire and Brenda L. Powell and Michelle Jennens and Pamela A. McCaskie and Kim W. Carter and Lyle John Palmer and Peter G. L. Thompson and Brendan M. McQuillan and Joseph Hung and John P Beilby},
  journal={Human Genetics},
  year={2008},
  volume={123},
  pages={307-313}
}
Endothelin-1 is a potent vasoconstrictor in the body. Previous studies have identified associations between the coding polymorphism K198N and hypertension, systolic blood pressure and HDL levels. We sought to examine the evidence for these associations and, additionally, the association between K198N, insulin resistance, metabolic syndrome and coronary artery disease (CAD). We used generalised linear modelling to test K198N for association with hypertension and systolic blood pressure, lipid… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

DeWnition of metabolic syndrome: report of the National Heart, Lung and Blood Institute/American Heart Association conference on scientiWc issues related to deWnition

  • SM Grundy, B JrBrewer, JI Cleeman, SC JrSmith, C Lenfant
  • Circulation
  • 2004
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…