Investigating the antagonistic action between aspirin and tamoxifen with HSA: identification of binding sites in binary and ternary drug-protein systems by spectroscopic and molecular modeling approaches.

@article{Pourgonabadi2011InvestigatingTA,
  title={Investigating the antagonistic action between aspirin and tamoxifen with HSA: identification of binding sites in binary and ternary drug-protein systems by spectroscopic and molecular modeling approaches.},
  author={Sanaz Pourgonabadi and M. Saberi and J. Chamani},
  journal={Protein and peptide letters},
  year={2011},
  volume={18 3},
  pages={
          305-17
        }
}
The combination of several drugs is often necessary, especially during long-term therapy. A competitive binding of the drugs can cause a decrease of the amount of drugs actually bound to the protein and increase the biologically active fraction of the drug. The aim of this study has been to analyze the interactions of tamoxifen (TMX) and aspirin (ASA) with human serum albumin (HSA) and to evaluate the mechanism of a simultaneous binding of TMX and ASA to the protein. Fluorescence analysis was… Expand
Spectroscopic and cytotoxicity studies on the combined interaction of (-)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin.
  • Qingying Guo, Min Liu, +5 authors J. Han
  • Chemistry, Medicine
  • Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
  • 2019
Interaction of aspirin and vitamin C with bovine serum albumin.
...
1
2
...

References