Investigating the Spatial Associations Between Amyloid-β Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer’s Disease

  title={Investigating the Spatial Associations Between Amyloid-$\beta$ Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer’s Disease},
  author={L{\'i}lia Jorge and Ricardo Martins and N{\'a}dia Can{\'a}rio and Carolina Xavier and Antero J. Abrunhosa and Isabel Santana and Miguel Castelo‐Branco},
  journal={Journal of Alzheimer's Disease},
  pages={113 - 132}
Background: It has been proposed that amyloid-β (Aβ) plays a causal role in Alzheimer’s disease (AD) by triggering a series of pathologic events—possibly including neuroinflammation—which culminate in progressive brain atrophy. However, the interplay between the two pathological molecular events and how both are associated with neurodegeneration is still unclear. Objective: We aimed to estimate the spatial inter-relationship between neurodegeneration, neuroinflammation and Aβ deposition in a… 

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