Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA

@inproceedings{Nagano2015InvestigatingTR,
  title={Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA},
  author={Soshichiro Nagano and Eiko Seki and Ting-Yu Lin and Mikako Shirouzu and Shigeyuki Yokoyama and Jonathan Heddle and Georges Snounou},
  booktitle={PloS one},
  year={2015}
}
Malaria remains as one of the most deadly diseases in developing countries. The Plasmodium causative agents of human malaria such as Plasmodium falciparum possess an organelle, the apicoplast, which is the result of secondary endosymbiosis and retains its own circular DNA. A type II topoisomerase, DNA gyrase, is present in the apicoplast. In prokaryotes this enzyme is a proven, effective target for antibacterial agents, and its discovery in P. falciparum opens up the prospect of exploiting it… CONTINUE READING