Investigating the Pharmacology, Dimerisation and Receptor-Dependent Toxicology of Metabotropic Glutamate Receptor 5

@inproceedings{Weaver2017InvestigatingTP,
  title={Investigating the Pharmacology, Dimerisation and Receptor-Dependent Toxicology of Metabotropic Glutamate Receptor 5},
  author={Andrew Daniel Weaver},
  year={2017}
}
G protein-coupled receptors represent the largest family of druggable targets in the human genome, with over half of drugs currently on the market acting at these receptors. Metabotropic glutamate receptor 5 is one such receptor, thought to be involved in several neurological diseases such as schizophrenia, anxiety, and depression as well as many neurodegenerative disorders. Allosteric modulators, ligands which act at a site topographically different from that of the endogenous ligand, have… CONTINUE READING

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