Investigating the Pathogenic Role of PADI4 in Oesophageal Cancer

@inproceedings{Chang2011InvestigatingTP,
  title={Investigating the Pathogenic Role of PADI4 in Oesophageal Cancer},
  author={Xiaotian Chang and Xiuli Hou and Jihong Pan and Kehua Fang and Lin Wang and Jinxiang Han},
  booktitle={International journal of biological sciences},
  year={2011}
}
PADI4 post-translationally converts peptidylarginine to citrulline. PADI4 can disrupt the apoptotic process via the citrullination of histone H3 in the promoter of p53-target genes. The current study focused on PADI4 expression in various subtypes of oesophageal carcinoma (EC) by immunohistochemistry, western blotting and real time PCR. The study also investigated the effect of bile acid deoxycholate (DCA) on PADI4 expression in Eca-109 cells that originated from EC. Apoptosis and DCA-induced… CONTINUE READING
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PADI4 has increased expression in blood and tissues of malignant tumors

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  • 2009

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