Investigating the Impact of the Down Syndrome Related Common MTHFR 677C>T Polymorphism in the Danish Population

@inproceedings{Kokotas2009InvestigatingTI,
  title={Investigating the Impact of the Down Syndrome Related Common MTHFR 677C>T Polymorphism in the Danish Population},
  author={Haris Kokotas and Maria Grigoriadou and Margareta Mikkelsen and Aglaia Giannoulia-Karantana and Michael Bjorn Petersen},
  booktitle={Disease markers},
  year={2009}
}
Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usually the result of nondisjunction of chromosome 21 in meiosis in either oogenesis or spermatogenesis. To investigate the relationship between folate metabolism and Down syndrome (DS… CONTINUE READING