Investigating the Epigenetic Effects of a Prototype Smoke-Derived Carcinogen in Human Cells

@inproceedings{Tommasi2010InvestigatingTE,
  title={Investigating the Epigenetic Effects of a Prototype Smoke-Derived Carcinogen in Human Cells},
  author={Stella Tommasi and Sang-in Kim and Xueyan Zhong and Xiwei Wu and Gerd. P. Pfeifer and Ahmad Besaratinia},
  booktitle={PloS one},
  year={2010}
}
Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer. In this study, we have comprehensively investigated the modulation of DNA methylation consequent to chronic exposure to a prototype smoke-derived carcinogen, benzo[a]pyrene diol epoxide (B[a]PDE), in genomic regions of significance in lung cancer, in normal human cells. We have used a pulldown assay… CONTINUE READING