Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model

@inproceedings{Zampieri2009InvestigatingTC,
  title={Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model},
  author={Mattia Zampieri and Giuseppe Legname and Claudio Altafini},
  booktitle={PLoS Computational Biology},
  year={2009}
}
Prion proteins are known to misfold into a range of different aggregated forms, showing different phenotypic and pathological states. Understanding strain specificities is an important problem in the field of prion disease. Little is known about which PrP(Sc) structural properties and molecular mechanisms determine prion replication, disease progression and strain phenotype. The aim of this work is to investigate, through a mathematical model, how the structural stability of different… CONTINUE READING

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