Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population.

@article{Zeinaly2018InvestigatingTA,
  title={Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population.},
  author={Ilghar Zeinaly and Naghmeh Vossoughi and D Elieh Ali Komi and Tohid Kazemi and Zohreh Babaloo and Alireza Razavi and Mohammad Sajay-Asbaghi and Mahnaz Sadeghi-Shabestari},
  journal={Iranian journal of allergy, asthma, and immunology},
  year={2018},
  volume={17 6},
  pages={
          526-532
        }
}
Orosomucoid 1-like 3 (ORMDL3) gene, located on chromosome 17q21, is an asthma candidate gene that encodes ORMDL3. This molecule has been reported to play a role in airway remodeling and bronchial hyper-responsiveness. In this study, we aimed to investigate the possible association of ORMDL3 single nucleotide polymorphism (SNP) (rs12603332) with susceptibility to allergic asthma in Iranian Northwestern Azeri population. 193 asthmatic patients and 185 normal individuals were included. Genomic DNA… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Benomyl-induced effects of ORMDL3 overexpression via oxidative stress in human bronchial epithelial cells.

  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2016

Association between ORMDL3 polymorphism and susceptibility to asthma: a meta-analysis.

  • International journal of clinical and experimental medicine
  • 2015